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The University of Paris (French: Université de Paris), metonymically known as the Sorbonne (French: [sɔʁbɔn]), was the leading university in Paris, France, active from 1150 to 1970, with the exception of 1793–1806 under the French Revolution. Emerging around 1150 as a corporation associated with the cathedral school of Notre Dame de Paris, it was considered the second-oldest university in Europe.
Internationally highly reputed for its academic performance in the humanities ever since the Middle Ages – notably in theology and philosophy – it introduced several academic standards and traditions that have endured ever since and spread internationally, such as doctoral degrees and student nations. Vast numbers of popes, royalty, scientists, and intellectuals were educated at the University of Paris. A few of the colleges of the time are still visible close to the Panthéon and Jardin du Luxembourg: Collège des Bernardins (18 rue de Poissy, 5th arr.), Hôtel de Cluny (6 Place Paul Painlève, 5th arr.), Collège Sainte-Barbe (4 rue Valette, 5th arr.), Collège d’Harcourt (44 Boulevard Saint-Michel, 6th arr.), and Cordeliers (21 rue École de Médecine, 6th arr.).
In 1793, during the French Revolution, the university was closed, and by Item 27 of the Revolutionary Convention, the college endowments and buildings were sold. A new University of France replaced it in 1806 with four independent faculties: the Faculty of Humanities (French: Faculté des Lettres), the Faculty of Law (later including Economics), the Faculty of Science, the Faculty of Medicine and the Faculty of Theology (closed in 1885).
In 1970, following the civil unrest of May 1968, the university was divided into 13 autonomous universities.
AP-HP, Inserm and Université Paris Cité extend their congratulations to Professor Guillaume Canaud’s teams at Necker-Enfants Malades Hospital (AP-HP), Necker-Enfants Malades Institute (INEM), Inserm, Institut Imagine and Université Paris Cité for their work on alpelisib (BYL719), approved by the U.S. Food and Drug Administration (FDA). It is the first and only treatment for adult and pediatric patients 2 years old and older suffering from the PIK3CA-related overgrowth spectrum (PROS). PROS is an umbrella designation that gathers disorders related to PIK3CA gain of function mutation including CLOVES syndrome, Klippel Trenaunay syndrome, macrodactyly and megalencephaly. Patients with PROS usually present with major deformities and vascular swellings. where to buy a fake University of Paris certificate? buy fake University of Paris diploma, buy fake University of Paris degree, buy fake University of Paris certificate. make fake University of Paris diploma, buy fake diploma, buy fake degree, buy fake degree certificate. In the most severe forms, there are fatty tissue outgrowths, vascular malformations, scoliosis, skeletal manifestations such as major bone enlargement, and organ deformities such as the brain or kidneys.
This approval is based on the results of the EPIK-P1 study conducted by using real-world data by the teams of Prof. Guillaume Canaud at Necker-Enfants Malades Hospital (AP-HP), Necker-Enfants Malades Institute (INEM), Inserm, Institut Imagine and Université Paris Cité – Novartis Promotion for whom he was the principal investigator.
This retrospective study of 57 patients, 44 of which were hospitalised at Necker Enfants Malades Hospital (AP-HP), showed the efficacy of alpelisib (a drug used in breast cancer) in pediatric and adult patients with PROS. Patients treated with this molecule experienced a reduction in the volume of the target lesion and a significant improvement in the symptoms and manifestations linked to PROS2.
This study followed research conducted between 2016 and 2018 at Necker Enfants Malades/Université Paris Cité/INSERM by Dr. Canaud and his group were they identifed alpelisib as a promising therapeutic for PROS and demonstrated its efficacy in a preclincial model that they specially created. Based the major impact that this drug had on the mouse model they carried out a proof of concept in 19 patients with severe form of PROS including adults and children. The outstandin results were published in the journal Nature3.
Since 2016, just over 150 patients have been treated, including two infants who were the focus of a recently published study 4 . Where to buy a fake University of Paris diploma? where to buy a fake University of Paris degree? where to buy a fake University of Paris certificate? buy fake University of Paris diploma.
Up until now, no therapeutic treatment was available for patients whose prognosis could be at risk in the short or medium term and for whom the only therapeutic options consisted of symptomatic treatments and, in the most serious cases, embolisations or mutilating surgeries to preserve the healthy organs or limbs.